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"Its permission to make products using propylene glycol (PG) is cancelled, and it is allowed to make and sell all other products." The Marion factory in Uttar Pradesh was closed in March, after an analysis last year by Uzbekistan's health ministry of two cough syrups made by Marion, Ambronol and DOK-1 Max. India's pharmaceuticals department told parliament that tests had also shown that a sample of propylene glycol (PG), an ingredient of cough syrups taken from Marion's factory contained EG. Reuters has reported that DEG and EG have been used by unscrupulous actors as a substitute for propylene glycol because they are cheaper. Uzbek state prosecutors told a court in Tashkent that distributors of the contaminated Marion syrups paid officials a bribe of $33,000 to skip mandatory testing there.

Persons: Anushree, Shashi Mohan Gupta, Gupta, Rajeev Singh Raghuvanshi, Marion, syrups, Marion syrups, Krishna N, Saurabh Sharma, Clarence Fernandez Organizations: Marion Biotech, Emenox, REUTERS, Reuters, World Health Organization, WHO, EG, Thomson Locations: Uzbekistan, Noida, India, DELHI, Uttar Pradesh, Gambia, Cameroon, Marion, Ambronol, Tashkent

☆ Uzbekistan says contaminated Indian cough syrup was on market due to bribery
▼ + stars: | 2023-08-16 | by ( ) www.reuters.com time to read: +2 min

Three of the defendants (an Indian and two Uzbekistan nationals) are executives of Quramax Medical, a company that sold medicines produced by India’s Marion Biotech, in Uzbekistan. Pratar, who spoke in court, denied the charges but admitted to handing over the sum to officials through an intermediary as a "token of appreciation". Officials have not said why 45 deaths had remained unreported since last year. State prosecutors also said on Wednesday that Quramax had imported Marion Biotech medicines at an inflated price via two Singapore-based intermediary companies, which prompted tax evasion charges. Reporting by Mukhammadsharif Mamatkulov Writing by Olzhas Auyezov; Editing by Sharon SingletonOur Standards: The Thomson Reuters Trust Principles.

Persons: Singh Raghvendra Pratar, Saidkarim Akilov, Quramax, Mukhammadsharif, Olzhas Auyezov, Sharon Singleton Organizations: Quramax, India's Marion Biotech, Central, India’s Marion Biotech, Marion Biotech, Thomson Locations: Uzbekistan, Tashkent, TASHKENT, India, Singapore

Two other cough syrups made in India killed 19 children in Uzbekistan around December, according to the Uzbekistan government. India's overall pharma exports in the April-June quarter rose 5% to $6.58 billion. COUNTRY VISITSPharmexcil delegations have visited countries including Nigeria, Egypt and Russia in recent months to allay any concerns about Indian drugs, he said. Apart from Gambia, no other country has asked for additional tests for Indian drugs since the deaths, he said. Manufacturing a drug in Europe or the United States costs more than 30% than in India, giving India a big advantage, he said.

Persons: syrups, Udaya Bhaskar, Bhaskar, drugmakers, Krishna N, Alison Williams Organizations: Reuters, World Health Organization, WHO, pharma, Pharmaceuticals Export, of India, India's pharma, Marion Biotech, Thomson Locations: DELHI, Gambia, India, Uzbekistan, United States, China, U.S, Nigeria, Egypt, Russia, South Africa, Brazil, Europe

The company, Marion Biotech, bought the ingredient — propylene glycol (PG) — from trader Maya Chemtech India, as reported by Reuters. "Marion bought commercial-grade propylene glycol," said a second source, an investigator, who declined to be named while the inquiry is ongoing. International standards allow only trace amounts of EG and DEG in pharmaceutical-grade propylene glycol. The toxins were found in cough syrups exported to Gambia by the other Indian company, Maiden Pharmaceuticals. India made it mandatory for companies to have their cough syrups tested before export from June.

Persons: Marion, Deepak Sharma, Max, Vijay Kumar, Tuhin Bhattacharya, Mool Singh, Atul Rawat, Jaya Jain, Sachin Jain, Rohan Gupta, syrups, Maiden, Saurabh Sharma, Krishna, Jennifer Rigby, Olzhas, Sara Ledwith, Michele Gershberg, Deepa Babington Organizations: Reuters, Marion Biotech, Indian, EG, World Health Organization, Authorities, . Police, Marion, Court, Maya, Maiden Pharmaceuticals, WHO, Thomson Locations: DELHI, Uzbekistan, India, Delhi, Marion, Uttar Pradesh, Allahabad, Gambia, Indonesia, London, Almaty

He warned that contaminated medicines could still be found for several years, because adulterated barrels of an essential ingredient may remain in warehouses. Cough syrups and the ingredient, propylene glycol, both have shelf-lives of around two years. Unscrupulous actors sometimes substitute propylene glycol with toxic alternatives, ethylene glycol and diethylene glycol, because they are cheaper, several pharmaceutical manufacturing experts told Reuters. The WHO said it has also offered help to Liberia and Cameroon – which recently signalled that it too may have contaminated cough syrups for sale. The contaminated syrups in Liberia were made by India's Synercare Mumbai, according to the Nigerian regulator.

Persons: Rutendo Kuwana, Kuwana, –, syrups, Naresh Kumar Goyal, QP Pharmachem, India's Synercare, Synercare, It's, Jennifer Rigby, Krishna N.Das, Edward McAllister, Stanley Widianto, Sumit Khanna, Sophie Yu, Sara Ledwith, Michele Gershberg Organizations: World Health Organization, WHO, Reuters, Pharmaceutical, Marshall, Indonesian, –, PT Universal Pharmaceutical Industries, AFI, Pharmaceuticals, Marion Biotech, Maiden Pharmaceuticals, Thomson Locations: LIBERIA, CAMEROON, Liberia, Nigeria, Gambia, Uzbekistan, Micronesia, Indonesian, – Timor Leste, Cambodia, Senegal, Philippines, Cameroon, syrups, Marshall Islands, India's Synercare Mumbai, Nigerian, Liberian, India, Panama, Delhi, Dakar, Jakarta, Ahmedabad, Beijing

☆ Exclusive: India may issue alert on Marion cough syrup exports after toxins found
▼ + stars: | 2023-03-04 | by ( Krishna N. Das | ) www.reuters.com time to read: +3 min

[1/2] Logo of Marion Biotech, a healthcare and pharmaceutical company is seen on a gate outside their office in Noida, India, December 29, 2022. REUTERS/Anushree FadnavisNEW DELHI, March 4 (Reuters) - India may issue an alert on cough syrup exported by Marion Biotech, whose products have been linked to deaths in Uzbekistan, after tests showed many of the company's drug samples contained toxins, a drug inspector said on Saturday. "The health ministry could issue an alert. Babbar has been part of a team that inspected Marion's plant four times after Uzbekistan said in December the children died after consuming the company's cough syrups. India in October suspended production at Maiden for violating manufacturing standards after the WHO said four of its cough syrups may have killed dozens of children in Gambia.

Two Marion directors were "out of the country and will be arrested as soon as they land in India," senior police official Ram Badan Singh told Reuters. Uzbekistan in December said the children died after consuming Marion's cough syrups. The same toxin was found in cough syrups exported to Gambia by another Indian company, Maiden Pharmaceuticals. India in October suspended production at Maiden for violations of manufacturing standards after the World Health Organization said four of its cough syrups may have killed dozens of children in Gambia. The deaths in Gambia and Uzbekistan have dented the image of the $41 billion pharmaceutical industry in India, which is known as the "pharmacy of the world."

☆ Exclusive: WHO investigating links between cough syrup deaths, considers advice for parents
▼ + stars: | 2023-01-24 | by ( Jennifer Rigby | ) www.reuters.com time to read: +6 min

The deaths of children from acute kidney injury began in July 2022 in Gambia, followed by cases in Indonesia and Uzbekistan. The WHO has said the deaths are linked to over-the-counter cough syrups the children took for common illnesses and which contained a known toxin, either diethylene glycol or ethylene glycol. The WHO, working with Indonesia’s drugs regulator, also issued an alert in October about cough syrups made by four Indonesian manufacturers and sold domestically. The manufacturers are: PT Yarindo Farmatama, PT Universal Pharmaceutical, PT Konimex, PT AFI Farma. PT Universal Pharmaceutical Industries’ lawyer, Hermansyah Hutagalung, said it had pulled from the market all cough syrups deemed dangerous.

☆ WHO urges 'immediate action' after cough syrup deaths
▼ + stars: | 2023-01-23 | by ( Jennifer Rigby | ) www.reuters.com time to read: +3 min

REUTERS/Anushree FadnavisLONDON, Jan 23 (Reuters) - The World Health Organization has called for "immediate and concerted action" to protect children from contaminated medicines after a spate of child deaths linked to cough syrups last year. The medicines, over-the-counter cough syrups, had high levels of diethylene glycol and ethylene glycol. It called for action across its 194 member states to prevent more deaths. It also issued a warning last year for cough syrups made by four Indonesian manufacturers, PT Yarindo Farmatama, PT Universal Pharmaceutical, PT Konimex and PT AFI Pharma, that were sold domestically. It also asked governments and regulators to assign resources to inspect manufacturers, increase market surveillance and take action where required.

☆ Indian maker of cough syrup linked to Uzbekistan deaths halts production
▼ + stars: | 2022-12-30 | by ( ) www.reuters.com time to read: +2 min

NEW DELHI, Dec 30 (Reuters) - The Indian maker of a cough syrup that was linked to the death of 19 children in Uzbekistan said on Friday that it had halted production of all medicines after an inspection by the drug regulator. Indian media reported that the inspectors had found deviation from rules on manufacturing at one of Marion Biotech's units. Uzbekistan's health ministry said at least 18 children died in Samarkand city after consuming Marion Biotech's Dok-1 Max syrup. Hasan Harris, Marion Biotech's legal head, told Reuters partner ANI, "We await the reports, the factory was inspected. The Uzbekistan case follows deaths of at least 70 children in Gambia that had been linked to cough and cold syrups manufactured by New Delhi-based Maiden Pharmaceuticals Ltd.

☆ Indian maker of syrup linked to Uzbekistan deaths halts production; facility inspected
▼ + stars: | 2022-12-29 | by ( ) www.reuters.com time to read: +2 min

REUTERS/Anushree FadnavisNEW DELHI, Dec 29 (Reuters) - India's drug regulator said on Thursday that it had inspected Marion Biotech's production facility and promised more action based on the probe report after the company's cough syrup was linked to death of 18 children in Uzbekistan. A legal representative of Marion Biotech said the Indian maker of pharmaceuticals and cosmetics regretted the deaths and the company has halted production of the Dok-1 Max syrup. The drug regulator reviewed the company's Noida facility in the Uttar Pradesh state and is in regular touch with its Uzbekistan counterpart, the Indian health ministry said in a statement. "The samples of the cough syrup have been taken from the manufacturing premises and sent to Regional Drugs Testing Laboratory, Chandigarh for testing," the ministry said. Uzbekistan's health ministry said on Wednesday that at least 18 children in the country died after consuming the syrup, manufactured by the Indian drugmaker.

☆ Uzbekistan says 18 children die after consuming India-made syrup
▼ + stars: | 2022-12-28 | by ( ) www.reuters.com time to read: +2 min

NEW DELHI, Dec 28 (Reuters) - Uzbekistan's health ministry has said at least 18 children have died after consuming a medicinal syrup manufactured by Indian drugmaker Marion Biotech Pvt Ltd. The ministry said 18 out of 21 children who took the Doc-1 Max syrup while suffering from an acute respiratory disease died after consuming it. The syrup was imported into Uzbekistan by Quramax Medical LLC, the ministry said in its statement released on Tuesday. An Indian government source said the health ministry was looking into the matter. The Uzbek health ministry said it had dismissed seven employees for negligence for not analysing the deaths in a timely manner and not taking the necessary measures.

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